4-Hydroxybenzyl alcohol

A phenol with diverse biological activities

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Background

4-Hydroxybenzyl alcohol is a phenol and an aglycone form of gastrodin that has been found in Gastrodia and has diverse biological activities.^1,2,3,4 It inhibits LPS-induced production of nitric oxide (NO) and reactive oxygen species (ROS) and decreases inducible nitric oxide synthase (iNOS), but not COX-2, levels in RAW 264.7 cells when used at concentrations of 0.5 and 1 mM.² 4-Hydroxybenzyl alcohol (1.5 and 4.5 mg/animal) reduces exudate volume and leukocyte infiltration in a rat model of carrageenan-induced air pouch inflammation, and inhibits acetic acid-induced writhing in mice when administered at doses of 50 and 100 mg/kg. It reduces infarct volume and the number of TUNEL-positive neurons in the ipsilateral cortex in a rat model of focal cerebral ischemia induced by transient middle cerebral artery occlusion (MCAO) when administered at a dose of 50 mg/kg.³ 4-Hydroxybenzyl alcohol (50 and 100 mg/kg) increases the number of entries into, and the percentage of time spent in, the open arms of the elevated plus maze in mice, indicating anxiolytic-like activity.⁴

1.Hsieh, M.-T., Wu, C.-R., and Chen, C.-F.Gastrodin and p-hydroxybenzyl alcohol facilitate memory consolidation and retrieval, but not acquisition, on the passive avoidance task in ratsJ. Ethnopharmacol.56(1)45-54(1997) 2.Lim, E.-J., Kang, H.-J., Jung, H.-J., et al.Anti-angiogenic, anti-inflammatory and antinociceptive activity of 4-hydroxybenzyl alcoholJ. Pharm. Pharmacol.59(9)1235-1240(2007) 3.Yu, S.-S., Zhao, J., Zheng, W.-P., et al.Neuroprotective effect of 4-hydroxybenzyl alcohol against transient focal cerebral ischemia via anti-apoptosis in ratsBrain Res.1308167-175(2010) 4.Jung, J.W., Yoon, B.H., Oh, H.R., et al.Anxiolytic-like effects of Gastrodia elata and its phenolic constituents in miceBiol. Pharm. Bull.29(2)261-265(2006)