Clidinium bromide (Ro 2-3773)

A muscarinic receptor antagonist

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100mg

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Background

Clidinium is a gastrointestinal muscarinic receptor antagonist (K_i = 3 nM against [³H]quinuclidinyl benzilate binding in rat colonic enterocytes).¹ Administration of clidinium, at a dose of 1 mg/kg, slows intestinal transit and induces constipation in mice.² This clidinium-induced constipation induces serum hyperammonemia and decreases clonic, myoclonic, and tonic seizure thresholds in a murine pentylenetetrazole-induced epilepsy model.

1.Zimmerman, T.W., and Binder, H.J.Muscarinic receptors on rat isolated colonic epithelial cells. A correlation between inhibition of [3H]quinuclidinyl benzilate binding and alteration in ion transportGastroenterology83(6)1244-1251(1982) 2.Moezi, L., Pirsalami, F., and Inaloo, S.Constipation enhances the propensity to seizure in pentylenetetrazole-induced seizure models of miceEpilepsy Behav.44200-206(2015)