Tyramine

A monoamine and TAAR1 agonist

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
500mg

￥337.00

270.00

- +
1g

￥425.00

340.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajce46688
CAS: 51-67-2
别名: 酪胺
分子式: C8H11NO
分子量: 137.18
纯度: >98%
溶解度: DMF: 25 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 20 mg/ml,Ethanol: 5 mg/ml
储存: 4°C, protect from light
库存: 现货

Background

Tyramine is a tyrosine-derived endogenous and dietary monoamine and trace amine-associated receptor 1 (TAAR1) agonist.^1,2,3 It activates TAAR1 (EC₅₀s = 0.08, 0.69, and 2.26 ?M for rat, mouse, and human-rat chimera receptors, respectively).¹ Tyramine also inhibits the release of norepinephrine and dopamine in isolated rat caudate nucleus (IC₅₀s = 40.6 and 119 nM, respectively).⁴

1.Reese, E.A., Bunzow, J.R., Arttamangkul, S., et al.Trace amine-associated receptor 1 displays species-dependent stereoselectivity for isomers of methamphetamine, amphetamine, and para-hydroxyamphetamineJ. Pharmacol. Exp. Ther.321(1)178-186(2007) 2.Zucchi, R., Chiellini, G., Scanlan, T.S., et al.Trace amine-associated receptors and their ligandsBr. J. Pharmacol.149(8)967-978(2006) 3.Maguire, J.J., Parker, W.A.E., Foord, S.M., et al.International Union of Pharmacology. LXXII. Recommendations for trace amine receptor nomenclaturePharmacol. Rev.61(1)(2009) 4.Rothman, R.B., Baumann, M.H., Dersch, C.M., et al.Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotoninScience39(1)32-41(2001)