Glutathione oxidized (L-Glutathione oxidized)

An oxidized form of GSH

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100mg

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货号: ajce46948
CAS: 27025-41-8
别名: 氧化型谷胱甘肽; L-Glutathione oxidized; GSSG; Oxiglutatione
分子式: C20H32N6O12S2
分子量: 612.63
纯度: >98%
溶解度: Water : 33.33 mg/mL (54.40 mM)
储存: Store at -20°C
库存: 现货

Background

L-Glutathione, oxidized (GSSG) is an oxidized form of the antioxidant L-glutathione .¹ It is produced upon reduction of hydroperoxide by glutathione peroxidases (GPXs) and can be reduced back to GSH through the NADPH-dependent enzyme glutathione reductase (GR).^2,3 The reduced glutathione-to-oxidized glutathione (GSH/GSSG) ratio has been used as an indicator of oxidative stress.²

1.Pompella, A., Visvikis, A., Paolicchi, A., et al.The changing faces of glutathione, a cellular protagonistBiochem. Pharmacol.66(8)1499-1503(2003) 2.Johnson, F.D., Ferrarone, J., Liu, A., et al.Characterization of a small molecule inhibitor of disulfide reductases that induces oxidative stress and lethality in lung cancer cellsCell Rep.38(6)110343(2022) 3.Imai, H., and Nakagawa, Y.Biological significance of phospholipid hydroperoxide glutathione peroxidase (PHGPx, GPx4) in mammalian cellsFree Radic. Biol. Med.34(2)145-169(2003)