Aldose reductase-IN-1

An aldose reductase inhibitor

原价

￥1512-13775

价格

￥ 1210-11020

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产品引用

Cell.Cell host & microbe.November 8, 2023
Cell . MOLECULAR PLANT . 1 February 2023
Cell . Immunity . August 10, 2021
Nature Communications.1413 (2022)
ACS . Nano Lett . April 10, 2023

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Background

AT-001 is an inhibitor of aldose reductase (IC₅₀ = 28.9 pM).¹ It reduces infarct area in streptozotocin-induced diabetic mice expressing human aldose reductase in a model of cardiomyopathy induced by ischemia-reperfusion injury when administered at a dose of 40 mg/kg.²

1.Wasmuth, A., Landry, D., Deng, S.X., et al.Aldose reductase inhibitors and uses thereof(2014) 2.Perfetti, R., Rowell, P., Shendelman, S., et al.Preclinical and clinical proof of concept for metabolic intervention in diabetic cardiomyopathyJ. Card. Fail.25(8)S77(2019)

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生命科学

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Aldose reductase-IN-1

Aldose reductase-IN-1详情

Background