Emeramide (BDTH2)

An antioxidant heavy metal chelator

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库存: 现货

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100mg

￥537.00

430.00

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500mg

￥1200.00

960.00

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货号: ajce47584
CAS: 351994-94-0
别名: N,N'-二(2-巯基乙基)间苯二甲酰胺,BDTH2
分子式: C12H16N2O2S2
分子量: 284.4
纯度: >98%
溶解度: DMSO : 100 mg/mL (351.62 mM);Water : < 0.1 mg/mL (insoluble)
储存: Store at -20°C,unstable in solution, ready to use.
库存: 现货

Background

Emeramide is an antioxidant heavy metal chelator.¹ It prevents methylmercury-induced glutathione (GSH) loss, and cytotoxicity to, isolated mouse aortic endothelial cells when used at a concentration of 50 ?M. Emeramide (50 ?M) also prevents reactive oxygen species (ROS) production and cytotoxicity induced by bleomycin in primary bovine pulmonary artery endothelial cells.² It increases survival of rats in a model of mercury chloride-induced toxicity when administered at a dose of 2 mg/kg.³

1.Secor, J.D., Kotha, S.R., Gurney, T.O., et al.Novel lipid-soluble thiol-redox antioxidant and heavy metal chelator, N,N'-bis(2-mercaptoethyl)isophthalamide (NBMI) and phospholipase D-specific inhibitor, 5-fluoro-2-indolyl des-chlorohalopemide (FIPI) attenuate mercury-induced lipid signaling leading to protection against cytotoxicity in aortic endothelial cellsInt. J. Toxicol.30(6)619-638(2011) 2.Patel, R.B., Kotha, S.R., Sauers, L.A., et al.Thiol-redox antioxidants protect against lung vascular endothelial cytoskeletal alterations caused by pulmonary fibrosis inducer, bleomycin: Comparison between classical thiol-protectant, N-acetyl-L-cysteine, and novel thiol antioxidant, N,N'-bis-2-mercaptoethyl isophthalamideToxicol. Mech. Methods22(5)383-396(2012) 3.Clarke, D., Buchanan, R., Gupta, N., et al.Amelioration of acute mercury toxicity by a novel, non-toxic lipid soluble chelator N,N'bis-(2-mercaptoethyl)isophthalamide: Effect on animal survival, health, mercury excretion and organ accumulationToxicol. Environ. Chem.94(3)616-640(2012)