NecroX-5

A necrosis inhibitor

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库存: 现货

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5mg

￥3050.00

2440.00

- +
10mg

￥4312.00

3450.00

- +
25mg

￥8637.00

6910.00

- +
50mg

￥13887.00

11110.00

- +

已选 0 种 0 瓶

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Background

Necrox-5 is a cell permeable inhibitor of necrosis that also demonstrates strong mitochondrial reactive oxygen species and ONOO^- scavenging activity.¹ It predominantly localizes in mitochondria, selectively blocking oxidative stress-induced necrotic cell death (0.1 μM necrox-5 inhibits ~50% cell death in H9C2 cells exposed to 400 μM t-BHP).¹ This compound has been shown to protect cells from oxidative stress, hypoxia, and cold shock in vitro, as well as carbon tetrachloride-induced liver injury and chronic liver fibrosis in rodent models.¹

1.Kim, H.J., Koo, S.Y., Ahn, B.H., et al.NecroX as a novel class of mitochondrial reactive oxygen species and ONOO- scavengerArch. Pharm. Res.33(11)1813-1823(2010)