A necrosis inhibitor
Necrox-5 is a cell permeable inhibitor of necrosis that also demonstrates strong mitochondrial reactive oxygen species and ONOO- scavenging activity.1 It predominantly localizes in mitochondria, selectively blocking oxidative stress-induced necrotic cell death (0.1 μM necrox-5 inhibits ~50% cell death in H9C2 cells exposed to 400 μM t-BHP).1 This compound has been shown to protect cells from oxidative stress, hypoxia, and cold shock in vitro, as well as carbon tetrachloride-induced liver injury and chronic liver fibrosis in rodent models.1
1.Kim, H.J., Koo, S.Y., Ahn, B.H., et al.NecroX as a novel class of mitochondrial reactive oxygen species and ONOO- scavengerArch. Pharm. Res.33(11)1813-1823(2010)
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