Squalene (Super Squalene)

A biosynthetic precursor to steroids

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库存: 现货

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5mg

￥250.00

200.00

- +
25mg

￥425.00

340.00

- +
50mg

￥675.00

540.00

- +
100mg

￥937.00

750.00

- +

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货号: ajce48674
CAS: 111-02-4
别名: 角鲨烯; Super Squalene; trans-Squalene; AddaVax
分子式: C30H50
分子量: 410.72
纯度: >98%
溶解度: DMSO : 16.67 mg/mL (40.59 mM);Water : < 0.1 mg/mL (insoluble)
储存: Store at -20°C
库存: 现货

Background

Squalene is a biosynthetic precursor to all steroids and a terpene originally isolated from shark liver oil.^1,2 Squalene is produced in mammals by condensation of two farnesyl diphosphate molecules by squalene synthase and then oxidized to squalene epoxide for use in the biosynthesis of lanosterol , cholesterol, and other steroids.¹ An oil-in-water emulsion of squalene synergistically increases adaptive immune responses to glucopyranosyl lipid adjuvant (GLA), a toll-like receptor 4 (TLR4) agonist, compared with an aqueous formulation of GLA.³ Formulations containing squalene have been used as adjuvants in vaccines and as hair and skin conditioning agents.

1.Tansey, T.R., and Shechter, I.Structure and regulation of mammalian squalene synthaseBiochim. Biophys. Acta1529(1-3)49-62(2000) 2.Kubota, B.The chemical composition of squaleneTokyo Kagaku Kaishi39879-907(1918) 3.Seydoux, E., Liang, H., Dubois Cauwelaert, N., et al.Effective combination adjuvants engage both TLR and inflammasome pathways to promote potent adaptive immune responsesJ. Immunol.201(1)98-112(2018)