Vincamine

A plant alkaloid with vasodilator effects

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库存: 现货

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100mg

￥537.00

430.00

- +
500mg

￥975.00

780.00

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Background

Vincamine is an indole alkaloid found in the leaves of V. minor and C. roseus that is used as a peripheral vasodilator to increase blood flow to the brain.¹ Vincamine contracts excised human cerebrovascular smooth muscle in vitro with an EC₅₀ value of 30 μM and has been explored as a pharmacotherapy to treat cerebral metabolic and vascular diseases.^2,3

1.Lim, C.C., and James, I.M.The effect of an acute infusion of vincamine and ethyl apovincaminate on cerebral blood flow in healthy volunteersBr. J. Clin. Pharmacol.9(1)100-101(1980) 2.Young, A.R., Bouloy, M., Boussard, J.F., et al.Direct vascular effects of agents used in the pharmacotherapy of cerebrovascular disease on isolated cerebral vesselsJ. Cereb. Blood Flow Metab.1(1)117-128(1981) 3.Nowicki, J.P., MacKenzie, E.T., and Spinnewyn, B.Effects of agents used in the pharmacotherapy of cerebrovascular disease on the oxygen consumption of isolated cerebral mitochondriaJ. Cereb. Blood Flow Metab.2(1)33-40(1982)