Senazodan

Senazodan是一种Ca2+感光剂，同时可抑制PDEIII的活性。

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库存: 现货

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数量
1mg

￥4275.00

3420.00

- +
5mg

￥8562.00

6850.00

- +
10mg

￥14400.00

11520.00

- +
20mg

￥25425.00

20340.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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Background

Senazodan is a Ca2+ sensitiser, and also shows inhibition effect on PDE III.

Senazodan seems to affect directly the actin-myosin crossbridge kinetics, and increase myosin ATPase activity[1]. Senazodan produces a concentration-dependent increase in tension development. Senazodan enhance Ca2+ binding to myofilaments and to purified cardiac troponin C. Senazodan also enhances contractility in guinea-pig papillary muscles by inhibiting PDE III[2].

[1]. Lehtonen LA, et al. Pharmacokinetics and pharmacodynamics of intravenous inotropic agents. Clin Pharmacokinet. 2004;43(3):187-203. [2]. Erhardt L. An emerging role for calcium sensitisation in the treatment of heart failure. Expert Opin Investig Drugs. 2005 Jun;14(6):659-70.