LAS-31180

LAS-31180是一种phosphodiesterase3的抑制剂，能够增强肌肉收缩和血管舒张。

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库存: 现货

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数量
1mg

￥4275.00

3420.00

- +
5mg

￥8562.00

6850.00

- +
10mg

￥14400.00

11520.00

- +
20mg

￥25425.00

20340.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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Background

LAS-31180 is an inhibitor of phosphodiesterase 3, with positive inotropic and vasodilator properties.

LAS 31180 shows positive inotropic activities in isolated guinea-pig ventricular strips (EC50 of 1.2 mumol/L) and in isolated guinea-pig working hearts[1].

In conscious chronically instrumented beagle dogs, LAS 31180 administered either by intravenous or oral route, shows a dose-dependent, long-lasting positive inotropic effect with minimal effects on heart rate. In hypertensive beagle dogs LAS 31180 elicits a potent and long-lasting fall in blood pressure[1].

[1]. Gras J, et al. Pharmacological profile of LAS 31180, a new inotropic/vasodilator quinolone derivative. Arzneimittelforschung. 2000 Nov;50(11):980-6.