SM-6586是一种calciumchannel的拮抗剂，同时能够抑制Na+/H+和Na+/Ca2+exchangetransport，主要用于研究脑血管疾病和高血压等疾病。
SM-6586 is a calcium channel antagonist and inhibitor of Na+/H+ and Na+/Ca2+ exchange transport, potentially for the treatment of cerebrovasular diseases and hypertension.
In SM-6586-treated spontaneously hypertensive rats, the survival rate after bilateral common carotid artery ligation is higher, the brain water content is lower, and the ATP level is higher and lactate level. In focal ischemia models, the SM-treated group shows a reduction of T1 relaxation time. The brain water content is significantly decreased in the SM-treated group[1].
[1]. Kashiwagi F, et al. Effect of a new calcium antagonist (SM-6586) on experimental cerebral ischemia. Acta Neurochir Suppl (Wien). 1994;60:289-92.
动态评分
0.0