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  • Efonidipine hydrochloride (NZ-105 hydrochloride)
Efonidipine hydrochloride (NZ-105 hydrochloride)的可视化放大

Efonidipine hydrochloride (NZ-105 hydrochloride)

An L- and T-type calcium channel inhibitor

原价
¥862-3450
价格
690-2760
Efonidipine hydrochloride (NZ-105 hydrochloride)的二维码

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  • 货号: ajce49388
  • CAS: 111011-53-1
  • 别名: 盐酸依福地平,NZ-105 hydrochloride
  • 分子式: C34H39ClN3O7P
  • 分子量: 668.12
  • 纯度: >98%
  • 溶解度: DMSO : 8.5 mg/mL (12.72 mM)
  • 储存: Store at -20°C
  • 库存: 现货

Background

Efonidipine is an inhibitor of L- and T-type voltage-gated calcium channels (Cavs).1 It inhibits Cav1.2a (IC50 = 1.8 nM for the hamster channel), an L-type Cav, and Cav3.2 (IC50 = 350 nM for the human channel), a T-type Cav. It also inhibits L- and T-type calcium channels and fetal bovine serum-induced hypertrophy in isolated mouse cardiomyocytes.2 Efonidipine (200 mg/kg) increases survival in a mouse model of acute myocardial infarction induced by ligation of the left coronary artery.3 Efonidipine is also an inhibitor of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro; IC50 = 38.5 ?M).4


1.Lee, T.-S., Kaku, T., Takebayashi, S., et al.Actions of mibefradil, efonidipine and nifedipine block of recombinant T- and L-type Ca2+ channels with distinct inhibitory mechanismsPharmacology78(1)11-20(2006) 2.Horiba, M., Muto, T., Ueda, N., et al.T-type Ca2+ channel blockers prevent cardiac cell hypertrophy through an inhibition of calcineurin-NFAT3 activation as well as L-type Ca2+ channel blockersLife Sci.82(11-12)554-560(2008) 3.Kinoshita, H., Kuwahara, K., Takano, M., et al.T-type Ca2+ channel blockade prevents sudden death in mice with heart failureCirculation120(9)743-752(2009) 4.Ghahremanpour, M.M., Tirado-Rives, J., Deshmukh, M., et al.Identification of 14 known drugs as inhibitors of the main protease of SARS-CoV-2ACS Med. Chem. Lett.11(12)2526-2533(2020)

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