Calcium channel-modulator-1

Calciumchannel-modulator-1是钙离子通道(calciumchannel)调节剂，阻塞主动脉收缩的IC50值为0.8μM。

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库存: 现货

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价格

促销价

数量
1mg

￥2150.00

1720.00

- +
5mg

￥4275.00

3420.00

- +
10mg

￥7262.00

5810.00

- +
20mg

￥12712.00

10170.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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Background

Calcium channel-modulator-1 is a calcium channel modulator; blocks aortic contraction with an IC50 of 0.8 μM.

Oral administration of Calcium channel-modulator-1 (20 mg/kg) causes a 35-37% decrease in systolic blood pressure in spontaneously hypertensive rats. However, iv administration of Calcium channel-modulator-1 to anesthetized spontaneously hypertensive rats causes a decrease in blood pressure which was more pronounced and long-lasting than that of nifedipine[1].

[1]. Sunkel CE, et al. Synthesis of 3-[(2,3-dihydro-1,1,3-trioxo-1,2-benzisothiazol-2-yl)alkyl] 1,4-dihydropyridine-3,5-dicarboxylate derivatives as calcium channel modulators. J Med Chem. 1992 Jun 26;35(13):2407-14.