Stibogluconate sodium (Sodium stibogluconate)

An anti-Leishmania antimony derivative

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500mg

￥600.00

480.00

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1g

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690.00

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货号: ajce49660
CAS: 16037-91-5
别名: 葡萄糖酸锑钠; Stibogluconate trisodium nonahydrate
分子式: C12H35Na3O26Sb2
分子量: 907.88
纯度: >98%
溶解度: Water : 9.1 mg/mL (9.99 mM);DMSO : < 1 mg/mL (insoluble or slightly soluble)
储存: Store at -20°C
库存: 现货

Background

Sodium stibogluconate is a pentavalent antimony derivative that is highly active against Leishmania amastigotes in macrophages.¹ Sodium stibogluconate has diverse effects on both this intracellular parasite and its host cell.^2,3

1.Roberts, W.L., and Rainey, P.M.Antileishmanial activity of sodium stibogluconate fractionsAntimicrob. Agents Chemother.37(9)1842-1846(1993) 2.Frézard, F., Demicheli, C., and Ribeiro, R.R.Pentavalent antimonials: New perspectives for old drugsMolecules14(7)2317-2336(2009) 3.Singh, N., Kumar, M., and Singh, R.K.Leishmaniasis: Current status of available drugs and new potential drug targetsAsian Pac. J. Trop. Med.5(6)485-497(2012)

Protocol

Cell experiment:

Human myeloid cell line TF-1 is maintained in RPMI 1640 supplemented with 10% FCS and 40 ng/mL recombinant human GM-CSF. For cell proliferation assays, cells are washed in 10% FCS medium twice, resuspended in 10% FCS medium, incubated at 37°C for 16 h, and then cultured at 37°C in 10% FCS medium containing various amounts of cytokines, sodium stibogluconate, or potassium antimonyl tartrate for 3-6 days. The cell numbers in proliferation assays are determined by an MTT assay or by microscopic cell counting[1].

Animal experiment:

BALB/c and athymic nude BALB/c mice are inoculated (s.c.) at the flanks with Renca cells (106 cells/site). Four days after inoculation, the mice are subjected to no treatment (control) or treatment with IL-2 (105 IU/day for 5 days i.p.), Stibogluconate sodium (12 mg/day i.m. at hip regions), or the combination of the two agents for 2 wk. Tumor volume is measured during the study period and calculated using the formula for a prolate spheroid[2].

参考文献:

[1]. Pathak MK, et al. Sodium stibogluconate is a potent inhibitor of protein tyrosine phosphatases and augments cytokine responses in hemopoietic cell lines. J Immunol. 2001 Sep 15;167(6):3391-7.
[2]. Fan K et al. Sodium Stibogluconate Interacts with IL-2 in Anti-Renca Tumor Action via a T Cell-Dependent Mechanism in Connection with Induction of Tumor-Infiltrating Macrophages. J Immunol. 2005 Nov 15;175(10):7003-8.