Pentagastrin (ICI-50123)

A CCK2 receptor agonist

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库存: 现货

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促销价

数量
5mg

￥600.00

480.00

- +
10mg

￥862.00

690.00

- +
25mg

￥1712.00

1370.00

- +
50mg

￥2812.00

2250.00

- +
100mg

￥4700.00

3760.00

- +

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Background

Pentagastrin is a synthetic polypeptide and cholecystokinin-2 (CCK₂) receptor agonist.¹ It binds selectively to CCK₂ receptors in guinea pig brain over CCK₁ receptors in rat pancreas (IC₅₀s = 11 and 1,100 nM, respectively). Pentagastrin increases calcium influx and polyphosphoinositide turnover in rat GH3 pituitary cells (EC₅₀s = 23 and 3.9 nM, respectively). It also increases histidine decarboxylase activity in mucous- and endocrine cell-enriched isolated rabbit fundic mucosal cells (EC₅₀ = 2.9 nM).² Pentagastrin induces contraction of isolated pig ileum smooth muscle cells in vitro (EC₅₀ = 30 pM).³ It increases gastric acid and pepsin secretion in conscious cats in vivo (ED₅₀s = 1.29 and 57.3 nmol/kg² per hour, respectively).⁴ Formulations containing pentagastrin have previously been used as a diagnostic aid to evaluate gastric acid secretory function.

1.Smith, A.J., and Freedman, S.B.CCK-B receptor-mediated stimulation of polyphosphoinositide turnover in GH3 pituitary cells in response to cholecystokinin and pentagastrinLife Sci.58(11)883-895(1996) 2.Hollande, F., Bali, J.P., and Magous, R.Neurohormonal regulation of histamine synthesis in isolated rabbit fundic mucosal cellsAm. J. Physiol.266(3 Pt. 1)G395-G405(1994) 3.Botella, A., Delvaux, M., Berry, P., et al.Cholecystokinin and gastrin induce cell contraction in pig ileum by interacting with different receptor subtypesGastroenterology102(3)779-786(1992) 4.Vagne, M., Collinet, M., Cuber, J.C., et al.Effect of porcine gastrin releasing peptide on gastric secretion and motility and the release of hormonal peptides in conscious cats.Peptides8(3)423-430(1987)