PF-06840003 (EOS200271)

An inhibitor of IDO-1

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库存: 现货

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数量
1mg

￥600.00

480.00

- +
5mg

￥912.00

730.00

- +
10mg

￥1512.00

1210.00

- +
50mg

￥4800.00

3840.00

- +
100mg

￥8025.00

6420.00

- +

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货号: ajce50000
CAS: 198474-05-4
别名: 3-(5-氟-1H-吲哚-3-基)-2,5-吡咯烷二酮,EOS200271
分子式: C12H9FN2O2
分子量: 232.21
纯度: >98%
溶解度: DMSO : ≥ 28 mg/mL (120.58 mM)
储存: Store at -20°C
库存: 现货

Background

EOS200271 is an inhibitor of indoleamine 2,3-dioxygenase 1 (IDO-1; IC₅₀ = 0.15 ?M for the human enzyme).¹ It is selective for IDO-1 over IDO-2 up to a concentration of 200 ?M for the human recombinant enzymes. EOS200271 inhibits IDO-1-mediated production of kynurenine induced by IFN-γ in HeLa cells (IC₅₀ = 1.8 ?M) and by LPS and IFN-γ in THP-1 cells and human-derived whole blood ex vivo (IC₅₀s = 1.7 and 4.7 ?M, respectively).

1.Crosignani, S., Bingham, P.M., Bottemanne, P., et al.Discovery of a novel and selective indoleamine 2,3-dioxygenase (IDO-1) inhibitor 3-(5-fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and its characterization as a potential clinical candidateJ. Med. Chem.60(23)9617-9629(2017)