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- Ligand for Target Protein for PROTAC
- N33-TEG-COOH (N3-TEG-COOH)
N33-TEG-COOH (N3-TEG-COOH)
N33-TEG-COOH (N3-TEG-COOH) (N3-TEG-COOH) 是一种基于 PEG 的 PROTAC 接头，可用于 PROTACs 的合成。
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100mg￥950.00855.00- +
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- 货号: ajce50152
- CAS: 201467-81-4
- 别名: 叠氮-四聚乙二醇-乙酸,N3-TEG-COOH; 14-Azido-3,6,9,12-tetraoxatetradecanoic acid
- 分子式: C10H19N3O6
- 分子量: 277.27
- 纯度: ＞98%
- 溶解度: DMSO : ≥ 100 mg/mL (360.66 mM)
- 储存: Store at -20°C
- 库存: 现货
Background
N33-TEG-COOH is a PROTAC linker containing four polyethylene glycol (PEG) units.
N33-TEG-COOH is a long linker extracted from Reference PMID: 26035625, Compound 7. A PROTAC is a heterobifunctional compound that contains two ligands connected by a linker unit. One ligand binds an E3 ubiquitin ligase protein, while the other ligand binds to the target protein of interest, thereby bringing the ligase and the target in close proximity[1].
[1]. Zengerle M, et al. Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4. ACS Chem Biol. 2015 Aug 21;10(8):1770-7.
