BHPI

An ERα antagonist

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库存: 现货

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2mg

￥1212.00

970.00

- +
5mg

￥1625.00

1300.00

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10mg

￥2812.00

2250.00

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50mg

￥9825.00

7860.00

- +

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Background

BHPI is an antagonist of estrogen receptor α (ERα) that blocks 17β-estradiol-induced proliferation of drug-resistant breast, endometrial, and ovarian cancer cell lines at concentrations ranging from 10 to 1,000 nM.¹ It is effective in vivo, driving tumor regression in mice bearing MCF-7 xenografts at a dose of 15 mg/kg daily.¹ BHPI specifically inhibits ERα-dependent gene expression and protein synthesis by activating the unfolded protein response in cells.¹

1.Andruska, N.D., Zheng, X., Yang, X., et al.Estrogen receptor α inhibitor activates the unfolded protein response, blocks protein synthesis, and induces tumor regressionProc. Natl. Acad. Sci. USA112(15)4737-4742(2015)