A small-molecule inhibitor of TNFα activity
Tumor necrosis factor α (TNFα) is a primary mediator of many inflammatory conditions including rheumatoid arthritis, toxic shock, and sepsis.1,2,3 TNFα functions as a trimer and promotes receptor trimerization to activate proinflammatory and/or apoptotic signalling pathways. 4,5 SPD-
1.Beutler, B., Greenwald, D., Hulmes, J.D., et al.Identity of tumor necrosis factor and the macrophage-secreted factor cachectinNature316552-554(1985) 2.Tracey, K.J., Beutler, B., Lowry, S.F., et al.Shock and tissue injury induced by recombinant human cachectinScience234470-474(1986) 3.Bidgood, M.J., Jamal, O.S., Cunningham, A.M., et al.Type IIA secretory phospholipase A2 up-regulates cyclooxygenase-2 and amplifies cytokine-mediated prostaglandin production in human rheumatoid synoviocytesJ. Immunol.1652790-2797(2000) 4.Thornberry, N.A., and Lazebnik, Y.Caspases: Enemies withinScience281(5381)1312-1316(1998) 5.Wallach, D., Varfolomeev, E.E., Malinin, N.L., et al.Tumor necrosis factor receptor and Fas signaling mechanismsAnnu. Rev. Immunol.17133-167(1999) 6.He, M.M., Smith, A.S., Oslob, J.D., et al.Small-molecule inhibition of TNF-αScience3101022-1025(2005)
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