Protease-Activated Receptor-4

Protease-ActivatedReceptor-4是转化生长因子受体4的激动剂。

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5mg

￥950.00

760.00

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10mg

￥1662.00

1330.00

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25mg

￥3625.00

2900.00

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Background

Protease-Activated Receptor-4 is the agonist of proteinase-activated receptor-4 (PAR4).

GYPGKF-NH2 significantly reduces the agonistic potency of AYPGKF-NH2 by 25-fold[1]. GYPGKF-NH2 (500 μM) does not cause contraction or relaxation of the guinea pig IAS strips[2].

[1]. Moschonas IC, et al. Molecular requirements involving the human platelet protease-activated receptor-4 mechanism of activation by peptide analogues of its tethered-ligand. Platelets. 2017 Mar 7:1-10. doi: 10.1080/09537104.2017.1282607. [Epub ahead of print] [2]. Huang SC, et al. Proteinase-activated receptor-1 (PAR1) and PAR2 mediate relaxation of guinea pig internal anal sphincter. Regul Pept. 2014 Feb 10;189:46-50.