Methacholine chloride

A muscarinic receptor agonist

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100mg

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货号: ajce51110
CAS: 62-51-1
别名: 醋甲胆碱; Acetyl-β-methylcholine chloride
分子式: C8H18ClNO2
分子量: 195.69
纯度: >98%
溶解度: DMSO : ≥ 42 mg/mL (214.63 mM)
储存: Store at -20°C, stored under nitrogen
库存: 现货

Background

Acetyl-β-methylcholine is a muscarinic (M) receptor agonist.¹ In wild-type mice, acetyl-β-methylcholine decreases heart rate and blood pressure and increases the airway pressure time index, a measure of bronchoconstriction, in a dose-dependent manner. Cardiac and pulmonary responses are abolished in M₂ and M₃ knockout mice, respectively, suggesting that acetyl-β-methylcholine acts on cardiac M₂ and pulmonary M₃ receptors. Formulations containing acetyl-β-methylcholine have been used to diagnose asthma and to monitor response to asthma therapies.²

1.Fisher, J.T., Vincent, S.G., Gomeza, J., et al.Loss of vagally mediated bradycardia and bronchoconstriction in mice lacking M2 or M3 muscarinic acetylcholine receptorsFASEB J.18(67)711-713(2004) 2.Choi, S.H., Sheen, Y.H., Kim, M.A., et al.Clinical implications of oscillatory lung function during methacholine bronchoprovocation testing of preschool childrenBiomed. Res. Int.20171-9(2017)