Trimethadione (3,5,5,-Trimethyloxazolidine-2,4-dione)

An anticonvulsant

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50mg

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货号: ajce51158
CAS: 127-48-0
别名: 三甲双酮,3,5,5,-Trimethyloxazolidine-2,4-dione
分子式: C6H9NO3
分子量: 143.14
纯度: >98%
溶解度: DMSO : ≥ 40 mg/mL (279.45 mM)
储存: Store at -20°C
库存: 现货

Background

Trimethadione is an anticonvulsant.^1,2 It decreases the levels of α-oxoglutarate, malate, and fumarate in the brain as well as plasma glucose levels in rats.¹ Trimethadione increases latency to first pentetrazole-induced clonic seizure in mice (ED₅₀ = 10 mg/kg).² It also inhibits absence-like seizures but not tonic convulsions in spontaneously epileptic rats.³

1.Nahorski, S.R.Biochemical effects of the anticonvulsants trimethadione, ethosuximide and chlordiazepoxide in rat brainJ. Neurochem.19(8)1937-1946(1972) 2.Frey, H.H.Determination of the anticonvulsant potency of unmetabolized trimethadioneActa. Pharmacol. Toxicol. (Copenh)27(4)295-300(1969) 3.Sasa, M., Ohno, Y., Ujihara, H., et al.Effects of antiepileptic drugs on absence-like and tonic seizures in the spontaneously epileptic rat, a double mutant ratEpilepsia29(5)505-513(1988)