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  • Cetrorelix Acetate (SB-075 acetate)
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Cetrorelix Acetate (SB-075 acetate)

A synthetic peptide GnRHR antagonist

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Cetrorelix Acetate (SB-075 acetate)的二维码
  • 库存: 现货
可选规格
  • 包装
    价格
    促销价
    数量
  • 1mg
    ¥600.00
    480.00
    - +
  • 5mg
    ¥1075.00
    860.00
    - +
  • 10mg
    ¥1775.00
    1420.00
    - +
  • 25mg
    ¥3562.00
    2850.00
    - +
  • 50mg
    ¥5125.00
    4100.00
    - +
已选 0 0
金额: ¥0.00
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  • 货号: ajce51176
  • CAS: 145672-81-7
  • 别名: 醋酸西曲瑞克; SB-75 acetate
  • 分子式: C72H96ClN17O16
  • 分子量: 1491.09
  • 纯度: >98%
  • 溶解度: DMSO : 50 mg/mL (33.53 mM)
  • 储存: -20°C, protect from light
  • 库存: 现货

Background

Cetrorelix is a synthetic peptide antagonist of the gonadotropin-releasing hormone receptor (GnRHR) with a Kd value of 0.2 nM for radioligand binding to murine LTK- cells expressing human GnRHR.1 It inhibits the activation of hGnRHR and a downstream luciferase reporter gene in murine LTK- cells by the GnRHR agonist [D-Trp6]GnRH (IC50 = 1.2 nM). In vivo, cetrorelix (60 μg per day) reduces tumor volume to 35% of control and decreases serum luteinizing hormone levels by 50% in a human epithelial ovarian cancer mouse xenograft model.2 Centrorelix (0.5 mg/kg) protects the primordial follicles (PMF) in mouse ovaries from damage induced by cyclophosphamide with 65% to 86% PMF survival compared to 46% PMF survival with a saline control.3 Formulations containing cetrorelix have been used to prevent ovulation during in vitro fertilization.


1.Beckers, T., Reil?nder, H., and Hilgard, P.Characterization of gonadotropin-releasing hormone analogs based on a sensitive cellular luciferase reporter gene assayAnal. Biochem.251(1)17-23(1997) 2.Yano, T., Pinski, J., Halmos, G., et al.Inhibition of growth of OV-1063 human epithelial ovarian cancer xenografts in nude mice by treatment with luteinizing hormone-releasing hormone antagonist SB-75Proc. Natl. Acad. Sci. USA91(15)7090-7094(1994) 3.Meirow, D., Assad, G., Dor, J., et al.The GnRH antagonist cetrorelix reduces cyclophosphamide-induced ovarian follicular destruction in miceHum. Reprod.19(6)1294-1299(2004)

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