5,6-Dihydrouridine

A pyrimidine nucleoside and derivative of uridine

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Background

5,6-Dihydrouridine is a pyrimidine nucleoside and derivative of uridine . It is present in, and provides conformational flexibility to, tRNA from bacteria, eukaryotes, and some archaea.^1,2 5,6-Dihydrouridine inhibits E. coli cytidine deaminase in a cell-free assay (K_i = 3.4 ?M).³ Serum levels of 5,6-dihydrouridine are increased in patients with prostate cancer and positively correlated with lethality.⁴

1.Kasprzak, J.M., Czerwoniec, A., and Bujnicki, J.M.Molecular evolution of dihydrouridine synthasesBMC Bioinformatics13153(2012) 2.Dalluge, J.J., Hashizume, T., Sopchik, A.E., et al.Conformational flexibility in RNA: The role of dihydrouridineNucleic Acids Res.24(6)1073-1079(1996) 3.Cohen, R.M., and Woldender, R.Cytidine deaminase from Escherichia coli. Purification, properties and inhibition by the potential transition state analog 3,4,5,6-tetrahydrouridineJ. Biol. Chem.246(24)7561-7656(1971) 4.Huang, J., Mondul, A.M., Weinstein, S.J., et al.Prospective serum metabolomic profiling of lethal prostate cancerInt. J. Cancer145(12)3231-3243(2019)