Esomeprazole potassium salt ((S)-Omeprazole potassium)

An H+/K+-ATPase inhibitor

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50mg

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货号: ajce51392
CAS: 161796-84-5
别名: 艾美拉唑钾盐,(S)-Omeprazole potassium salt; (-)-Omeprazole potassium salt
分子式: C17H18KN3O3S
分子量: 383.51
纯度: >98%
溶解度: Soluble in DMSO
储存: Store at -20°C
库存: 现货

Background

Esomeprazole is an inhibitor of the gastric H⁺/K⁺-ATPase and the (S) enantiomer of omeprazole .¹ It reversibly inhibits the activity of the H⁺/K⁺-ATPase in an enzyme assay. Esomeprazole (30 mg/kg, s.c.) inhibits histamine-induced gastric acid secretion in rats. Formulations containing esomeprazole in complex with magnesium have been used as proton pump inhibitors (PPIs) in the treatment of gastroesophageal reflux disease (GERD), H. pylori eradication, and hypersecretory conditions, as well as in the prevention of non-steroidal anti-inflammatory drug-related gastric ulcer.

1.Shin, J.M., and Sachs, G.Restoration of acid secretion following treatment with proton pump inhibitorsGastroenterology123(5)1588-1597(2002)