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  • Quin-2AM (Quin-2 acetoxymethyl ester)
Quin-2AM (Quin-2 acetoxymethyl ester)的可视化放大

Quin-2AM (Quin-2 acetoxymethyl ester)

A cell-permeant precursor of quin-2

原价
¥4162-4162
价格
3330-3330
Quin-2AM (Quin-2 acetoxymethyl ester)的二维码

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  • 货号: ajce51416
  • CAS: 83104-85-2
  • 别名: 钙荧光探针QUIN2-AM,Quin-2 acetoxymethyl ester
  • 分子式: C38H43N3O18
  • 分子量: 829.76
  • 纯度: >98%
  • 溶解度: Soluble in DMSO
  • 储存: Store at -20°C
  • 库存: 现货

Background

Quin-2 AM is a cell-permeant acetoxymethyl ester of the high affinity fluorescent calcium indicator quin-2 . As quin-2 AM enters cells, it is hydrolyzed by intracellular esterases to produce quin-2. Quin-2 binds calcium with a Kd value of 115 nM.1 It displays high selectivity for calcium, as it is not affected by sodium gradients, membrane potential, or intracellular pH.1 High affinity probes like quin-2 are ideal for monitoring low levels of calcium, as are found in resting cells.1,2 Loadings of up to 2 mM quin-2 are without serious toxic effects, so quin-2 may be used to buffer intracellular calcium transients. Excitation and emission maxima for quin-2 are 339 and 492 nm, respectively.


1.Tsien, R.Y., Pozzan, T., and Rink.T.J.Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicatorJ. Cell. Biol.947(2)325-334(1982) 2.Minta, A., Kao, J.P., and Tsien, R.Y.Fluorescent indicators for cytosolic calcium based on rhodamine and fluorescein chromophoresJ. Biol. Chem.264(14)8171-8178(1989)

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