Quin-2AM (Quin-2 acetoxymethyl ester)

A cell-permeant precursor of quin-2

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1mg

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货号: ajce51416
CAS: 83104-85-2
别名: 钙荧光探针QUIN2-AM,Quin-2 acetoxymethyl ester
分子式: C38H43N3O18
分子量: 829.76
纯度: >98%
溶解度: Soluble in DMSO
储存: Store at -20°C
库存: 现货

Background

Quin-2 AM is a cell-permeant acetoxymethyl ester of the high affinity fluorescent calcium indicator quin-2 . As quin-2 AM enters cells, it is hydrolyzed by intracellular esterases to produce quin-2. Quin-2 binds calcium with a K_d value of 115 nM.¹ It displays high selectivity for calcium, as it is not affected by sodium gradients, membrane potential, or intracellular pH.¹ High affinity probes like quin-2 are ideal for monitoring low levels of calcium, as are found in resting cells.^1,2 Loadings of up to 2 mM quin-2 are without serious toxic effects, so quin-2 may be used to buffer intracellular calcium transients. Excitation and emission maxima for quin-2 are 339 and 492 nm, respectively.

1.Tsien, R.Y., Pozzan, T., and Rink.T.J.Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicatorJ. Cell. Biol.947(2)325-334(1982) 2.Minta, A., Kao, J.P., and Tsien, R.Y.Fluorescent indicators for cytosolic calcium based on rhodamine and fluorescein chromophoresJ. Biol. Chem.264(14)8171-8178(1989)