5-Hydroxymethyluracil

Product of oxidative damage to DNA

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货号: ajce51468
CAS: 4433-40-3
别名: 5-羟甲基脲嘧啶
分子式: C5H6N2O3
分子量: 142.11
纯度: >98%
溶解度: DMF: 60 mg/ml,DMSO: 53 mg/ml,Ethanol: 0.8 mg/ml,PBS (7.2): 8 mg/ml
储存: Store at -20°C
库存: 现货

Background

Hydroxymethyl uracil is a product of oxidative damage to DNA, predominantly by hydroxyl radical via the Fenton reaction.^1,2,3

1.Zastawny, T.H., Altman, S.A., Randers-Eichhorn, L., et al.DNA base modifications and membrane damage in cultured mammalian cells treated with iron ionsFree Radic. Biol. Med.181013-1022(1995) 2.Spencer, J.P.E., Jenner, A., Chimel, K., et al.DNA strand breakage and base modification induced by hydrogen peroxide treatment of human respiratory tract epithelial cellsFEBS Lett.374(2)233-236(1995) 3.Jaruga, P., Zastawny, T.H., Skokowski, J., et al.Oxidative DNA base damage and antioxidant enzyme activities in human lung cancerFEBS Lett.34159-64(1994)