2-Guanidinoacetic acid

A metabolite of glycine and precursor in the biosynthesis of creatine

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货号: ajce51532
CAS: 352-97-6
别名: 胍基乙酸,Guanidinoacetic acid
分子式: C3H7N3O2
分子量: 117.11
纯度: >98%
溶解度: 1M HCl: 50 mg/mL (426.95 mM; ultrasonic and adjust pH to 1 with HCl); Water: < 0.1 mg/mL (insoluble)
储存: Store at -20°C
库存: 现货

Background

Glycocyamine is a metabolite of glycine and precursor in the biosynthesis of creatine.^1,2 It is formed from glycine by glycine amidinotransferase (GATM) in the kidney and pancreas, transported to the liver, and methylated by guanidinoacetate N-methyltransferase (GAMT) to form creatine.¹ Levels of glycocyamine are altered in individuals with cerebral creatine deficiency syndromes (CCDSs), inborn errors of metabolism characterized by deficiencies in GATM or GAMT.³

1.Ostojic, S.M.Cellular bioenergetics of guanidinoacetic acid: The role of mitochondriaJ. Bioenerg. Biomembr.47(5)369-372(2015) 2.Portocarero, N., and Braun, U.The physiological role of guanidinoacetic acid and its relationship with arginine in broiler chickensPoult. Sci.100(7)101203(2021) 3.Stockler, S., Schutz, P.W., and Salomons, G.S.Cerebral creatine deficiency syndromes: Clinical aspects, treatment and pathophysiologySubcell. Biochem.46149-166(2007)