Hydroquinidine (Dihydroquinidine)

An alkaloid and antiarrhythmic agent

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100mg

￥537.00

430.00

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货号: ajce51654
CAS: 1435-55-8
别名: 氢化奎宁定; Dihydroquinidine; (+)-Hydroquinidine; Hydroconquinine
分子式: C20H26N2O2
分子量: 326.43
纯度: >98%
溶解度: DMSO : ≥ 47 mg/mL (143.98 mM)
储存: 4°C, protect from light, stored under nitrogen
库存: 现货

Background

Hydroquinidine is an alkaloid and derivative of the antiarrhythmic agent quinidine that decreases heart rate variability.^1,2,3 It increases the length of the sinus cycle and prolongs QRS duration and ventricular repolarization in anesthetized dogs.² It has also been imprinted on microspheres as a pseudo-template molecule for recognition of cinchona alkaloids.³ Formulations containing hydroquinidine have been studied for use in treatment of Brugada syndrome, which is a genetic disorder characterized by ventricular fibrillation and a risk of sudden death.⁴

1.Chimienti, M., Regazzi, M.B., La Rovere, M.T., et al.Comparison of the effectiveness of dihydroquinidine and quinidine on ventricular ectopy after acute and chronic administrationCardiovasc. Drugs Ther.2(5)679-686(1988) 2.Chézalviel, F., Weissenburger, J., Ertzbischoff, O., et al.Comparison of the cardiac electrophysiological effects of flecainide and hydroquinidine in anesthetized dog: Concentration-response relationshipJ. Cardiovasc. Pharmacol.15(1)50-56(1990) 3.Zhou, Q., He, J., Tang, Y., et al.A novel hydroquinidine imprinted microsphere using a chirality-matching N-acryloyl-L-phenylalanine monomer for recognition of cinchona alkaloidsJ. Chromatogr. A.123860-67(2012) 4.Hermida, J.S., Denjoy, I., Clerc, J., et al.Hydroquinidine therapy in Brugada syndromeJ. Am. Coll. Cardiol.43(10)1853-1860(2004)