Emixustat hydrochloride (ACU-4429 hydrochloride)

An RPE65 inhibitor

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库存: 现货

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价格

促销价

数量
2mg

￥1200.00

960.00

- +
5mg

￥2150.00

1720.00

- +
10mg

￥3450.00

2760.00

- +
50mg

￥11762.00

9410.00

- +
100mg

￥18525.00

14820.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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Background

ACU 4429 is an inhibitor of retinal pigment epithelium 65 (RPE65; IC₅₀ = 4.4 nM), an enzyme that catalyzes the isomerization of 11-trans retinol to 11-cis retinol in the visual cycle.¹ It reduces rod photoreceptor recovery in dark-adapted mice after photobleaching (ED₅₀ = 0.21mg/kg) and reversibly decreases the regeneration of 11-cis retinal oxime in the same model (ED₅₀ = 0.18 mg/kg). ACU 4429 also prevents light-induced photoreceptor cell loss in dark-adapted albino mice. It reduces lipofuscin autofluorescence and decreases the level of retinoid toxin (A2E) in the RPE in an Abca4^-/- mouse model of Stargardt disease (ED₅₀ = 0.47 mg/kg).

1.Bavik, C., Henry, S.H., Zhang, Y., et al.Visual cycle modulation as an approach toward preservation of retinal integrityPLoS One10(5)e0124940(2015)