Elaidic acid

A trans fatty acid

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100mg

￥537.00

430.00

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货号: ajce51788
CAS: 112-79-8
别名: 反油酸
分子式: C18H34O2
分子量: 282.46
纯度: >98%
溶解度: DMSO : 13.5 mg/mL (47.79 mM);Water : < 0.1 mg/mL (insoluble)
储存: Store at -20°C
库存: 现货

Background

Elaidic acid is a monounsaturated trans fatty acid and the 9-trans isomer of oleic acid that has been found in partially hydrogenated cooking oils.¹ It reduces HHT and HETE formation and increases synthesis of prostaglandin E₂ , PGF₂α , PGD₂ , and thromboxane B₂ induced by arachidonic acid in isolated human platelets. Elaidic acid (0.1-5 mmol/L) induces apoptosis in human umbilical vein endothelial cells (HUVECs).² In vivo, elaidic acid (100 mg/kg) reduces cardiac and hepatic autophagy induced by palmitic acid in mice.³

1.Srivastava, K.C., and Awasthi, K.K.A comparative study on the effect of cis (oleic, linoleic) and trans (elaidic, linoelaidic) fatty acids on the in vitro prostaglandin biosynthesis in human blood platelets from (1-14C) arachidonic acidProstaglandins Leukot. Med.9(6)669-684(1982) 2.Zapolska-Downar, D., Ko?mider, A., and Naruszewicz, M.Trans fatty acids induce apoptosis in human endothelial cellsJ. Physiol. Pharmacol.56(4)611-625(2005) 3.Sauvat, A., Chen, G., Müller, K., et al.Trans-fats inhibit autophagy induced by saturated fatty acidsEBioMedicine30261-272(2018)