Xanthine

A purine base

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1g

￥650.00

520.00

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货号: ajce51934
CAS: 69-89-6
别名: 黄嘌呤
分子式: C5H4N4O2
分子量: 152.11
纯度: >98%
溶解度: 1M NaOH : 50 mg/mL (328.71 mM);DMSO : 3.33 mg/mL (21.89 mM; ultrasonic and warming and heat to 60°C)
储存: Store at 2-8°C
库存: 现货

Background

Xanthine is a purine base and intermediate in the biosynthesis of uric acid .^1,2 It is formed during mammalian purine catabolism in the liver via oxidation of hypoxanthine by xanthine oxidase (XO), which also oxidizes xanthine to produce uric acid.^1,3 Xanthine is also formed from guanine, xanthosine, or hypoxanthine during purine catabolism in plants.⁴ It has been found in a variety of commercial foodstuffs, including beer yeast, mushrooms, vegetables, fish, and beef.⁵ Urinary xanthine levels are decreased in patients with primary gout.⁶ Xanthine has also been used in the synthesis of xanthine derivatives that have anticancer or anti-inflammatory activities in vitro.⁷

1.Dawson, J., and Walters, M.Uric acid and xanthine oxidase: Future therapeutic targets in the prevention of cardiovascular disease?Br. J. Clin. Pharmac.62(6)633-644(2006) 2.Wu, S., Jia, S., and Dong, X.Study on detection methods for xanthine in food and biological samplesInt. J. Curr. Res. Chem. Pharm. Sci.3(8)(2016) 3.Garcia-Gil, M., Camici, M., Allegrini, S., et al.Emerging role of purine metabolizing enzymes in brain function and tumorsInt. J. Mol. Sci.19(11)3598(2018) 4.Zrenner, R., Stitt, M., Sonnewald, U., et al.Pyrimidine and purine biosynthesis and degradation in plantsAnnu. Rev. Plant Biol.57805-836(2006) 5.Kaneko, K., Aoyagi, Y., Fukuuchi, T., et al.Total purine and purine base content of common foodstuffs for facilitating nutritional therapy for gout and hyperuricemiaBiol. Pharm. Bull.37(5)709-721(2014) 6.Puig, J.G., Mateos, F.A., Jiménez, M.L., et al.Renal excretion of hypoxanthine and xanthine in primary goutAm. J. Med.85(4)533-537(1988) 7.Singh, N., Shreshtha, A.K., Thakur, M.S., et al.Xanthine scaffold: Scope and potential in drug developmentHeliyon4(10)e00829(2018)