Fludrocortisone acetate (9α-Fludrocortisone acetate)

A mineralocorticoid agonist

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100mg

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货号: ajce51938
CAS: 514-36-3
别名: 醋酸氟氢可的松; 9α-Fludrocortisone acetate; 9α-Fluorcortisol acetate
分子式: C23H31FO6
分子量: 422.49
纯度: >98%
溶解度: DMSO : ≥ 45 mg/mL (106.51 mM)
储存: Store at -20°C
库存: 现货

Background

Fludrocortisone acetate is the acetate form of the synthetic corticosteroid fludrocortisone, which is a mineralocorticoid receptor agonist.¹ Fludrocortisone acetate (0.1-5 ?g/animal) promotes sodium retention in rats in a dose-dependent manner with 37% of sodium excreted compared with control when used at a dose of 5 ?g/animal.² Formulations containing fludrocortisone acetate have been used in the treatment of Addison’s disease.

1.Agarwal, M.K., Coupry, F., and Philippe, M.Physiological activity and receptor binding of 9α fluorohydrocortisoneBiochem. Biophys. Res. Commun.78(2)747-753(1977) 2.Stafford, R.O., Barnes, L.E., Bowman, B.J., et al.Glucocorticoid and mineralocorticoids activities of Delta1-fluorohydrocortisoneProc. Soc. Exp. Biol. Med.89(3)371-374(1955)