Nitroprusside disodium dihydrate (Sodium nitroprusside dihydrate)

Sodium Nitroprusside Dihydrate is a potent vasodilator working through releasing NO spontaneously in blood.

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货号: ajce52260
CAS: 13755-38-9
别名: 硝普钠二水合物; Sodium nitroprusside dihydrate; Sodium Nitroferricyanide(III) Dihydrate
分子式: C5H4FeN6Na2O3
分子量: 297.95
纯度: >98%
溶解度: DMSO : ≥ 46 mg/mL (154.39 mM)
储存: 4°C, protect from light
库存: 现货

Background

Sodium Nitroprusside Dihydrate is a potent vasodilator working through releasing NO spontaneously in blood.

Sodium Nitroprusside is a potent vasodilator. Sodium nitroprusside has potent vasodilating effects in arterioles and venules. Sodium Nitroprusside breaks down in circulation to release nitric oxide (NO). NO activates guanylate cyclase in vascular smooth muscle and increases intracellular production of cGMP. The end result is vascular smooth muscle relaxation, which allow vessels to dilate. [1] Sodium nitroprusside decreases the proliferation of vascular smooth muscle cells. [2]

Sodium nitroprusside (5 mg/kg) significantly reduces the intestinal ischemiareperfusion injury as a nitric oxide donor in rats. [3]

[1] Wink DA, et al. Arch Biochem Biophys, 1996, 331(2), 241-8. [2] Garg UC, et al. J Clin Invest, 1989, 83(5), 1774-7. [3] Namazi H. Clinics (Sao Paulo), 2008, 63(3), 405.