Xenopsin

A neurotensin-like octapeptide

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1mg

￥537.00

430.00

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5mg

￥1612.00

1290.00

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10mg

￥2587.00

2070.00

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25mg

￥5562.00

4450.00

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Background

Xenopsin is a neurotensin-like octapeptide that has been found in X. laevis skin.¹ It inhibits neurotensin binding to rat brain synaptic membranes (K_i = 1.5 nM) and induces contraction of isolated guinea pig ileum in the presence of neostigmine .² Xenopsin (0.1 μM) increases the firing rate of dopaminergic neurons in rat substantia nigra slices by 58.5%.³ Intravenous infusion of xenopsin (2 μg/kg per hour) increases adrenal, pancreatic, and ileal blood flow and plasma levels of pancreatic polypeptide, glucagon, substance P, and cortisol, as well as reduces tetragastrin-induced gastric acid secretion in dogs.¹

1.Zinner, M.J., Kasher, F., Modlin, I.M., et al.Effect of xenopsin on blood flow, hormone release, and acid secretionAm. J. Physiol.243(3)G195-199(1982) 2.Granier, C., van Rietschoten, J., Kitabgi, P., et al.Synthesis and characterization of neurotensin analogues for structure/activity relationship studies. Acetyl-neurotensin-(8--13) is the shortest analogue with full binding and pharmacological activitiesEur. J. Biochem.124(1)117-124(1982) 3.Pozza, M.F., Küng, E., Bischoff, S., et al.The neurotensin analog xenopsin excites nigral dopamine neuronsEur. J. Pharmacol.145(3)341-343(1988)