Tetrahydroxyquinone (Tetrahydroxy-1,4-benzoquinone)

A redox-active hydroxyquinone

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100mg

￥537.00

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货号: ajce52472
CAS: 319-89-1
别名: 四羟基苯醌,Tetrahydroxy-1,4-benzoquinone; Tetrahydroxybenzoquinone
分子式: C6H4O6
分子量: 172.09
纯度: >98%
溶解度: DMSO : ≥ 1.8 mg/mL (10.46 mM)
储存: Store at -20°C
库存: 现货

Background

Tetrahydroxyquinone is a redox-active hydroxyquinone.^1,2 It inhibits HIV-1 proteinase (IC₅₀ = 575 ?M) and is active against T. brucei brucei (MIC₁₀₀ = 100 ?g/ml).^1,3 Tetrahydroxyquinone (100 ?M) induces the formation of reactive oxygen species (ROS) in, as well as apoptosis of, HL-60 leukemia cells.² It has also been used in the manufacturing of lithium-ion batteries.⁴

1.Brinkworth, R.I., and Fairlie, D.P.Hydroxyquinones are competitive non-peptide inhibitors of HIV-1 proteinaseBiochim. Biophys. Acta1253(1)5-8(1995) 2.Cavagis, A.D.M., Ferreira, C.V., Versteeg, H.H., et al.Tetrahydroxyquinone induces apoptosis of leukemia cells through diminished survival signalingExp. Hematol.34(2)188-196(2006) 3.Shapiro, A., Nathan, H.C., Hutner, S.H., et al.In vivo and in vitro activity by diverse chelators against Trypanosoma brucei bruceiJ. Protozool.29(1)85-90(1982) 4.Chen, H., Armand, M., Courty, M., et al.Lithium salt of tetrahydroxybenzoquinone: Toward the development of a sustainable Li-ion batteryJ. Am. Chem. Soc.131(25)8984-8988(2009)