25-Hydroxy VD2-D6

An internal standard for the quantification of 25-hydroxy vitamin D2

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500ug

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5010.00

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1mg

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5mg

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10mg

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Background

25-hydroxy Vitamin D₂-d₆ is intended for use as an internal standard for the quantification of 25-hydroxy vitamin D₂ by GC- or LC-MS. 25-hydroxy Vitamin D₂ is a metabolite of vitamin D₂ .¹ It is formed from vitamin D₂ by the cytochrome P450 (CYP) isoforms CYP2R1 and CYP27A1, which have 25-hydroxylase activity, and is bound to vitamin D binding protein (DBP) and albumin in the liver, then secreted into the bloodstream.² 25-hydroxy Vitamin D₂ is transported to the kidney, where it is preferentially 24-hydroxylated by CYP24A1 to produce 24,25-dihydroxy vitamin D₂.² It can also be hydroxylated by CYP27B1 to produce 1,25-dihydroxy vitamin D₂.^2,1 Serum levels of 25-hydroxy vitamin D₂ have been used as a marker of vitamin D status.³

1.DeLuca, H.F., Sicinski, R.P., Tanaka, Y., et al.Biological activity of 1,25-dihydroxyvitamin D2 and 24-epi-1,25-dihydroxyvitamin D2Am. J. Physiol.254(4 Pt 1)E402-406(1998) 2.Bikle, D.Vitamin D: Production, metabolism, and mechanisms of actionEndotext(2000) 3.Saenger, A.K., Laha, T.J., Bremner, D.E., et al.Quantification of serum 25-hydroxyvitamin D2 and D3 using HPLC-tandem mass spectrometry and examination of reference intervals for diagnosis of vitamin D deficiencyAm. J. Clin. Pathol.125(6)914-920(2006)