8-Hydroxyguanine

8-Hydroxyguanine是由活性氧物质产生的主要诱变前损伤。它导致G-T和A-C置换。

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5mg

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货号: ajce54650
CAS: 5614-64-2
别名: 2-氨基-6,8-二羟基嘌呤
分子式: C5H5N5O2
分子量: 167.13
纯度: >98%
溶解度: Water: < 0.1 mg/mL (insoluble); Ethanol: < 1 mg/mL (insoluble); DMSO: < 1 mg/mL (insoluble or slightly soluble)
储存: Store at -20°C
库存: 现货

Background

8-Hydroxyguanine is a major pre-mutagenic lesion generated from reactive oxygen species. It causes G-T and A-C substitutions. Human Endogenous Metabolite

[1]. Arai T, et al. High accumulation of oxidative DNA damage, 8-hydroxyguanine, in Mmh/Ogg1 deficient mice by chronic oxidative stress. Carcinogenesis. 2002 Dec;23(12):2005-10. [2]. Floyd RA, et al. The role of 8-hydroxyguanine in carcinogenesis. Carcinogenesis. 1990 Sep;11(9):1447-50. [3]. Cheng KC, et al. 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G----T and A----C substitutions. J Biol Chem. 1992 Jan 5;267(1):166-72.