Acetoacetic acid sodium salt

Acetoacetic acid sodium salt 是一种非酯化脂肪酸代谢物，参与人类糖尿病的发展。Acetoacetic acid sodium salt 诱导氧化应激，抑制牛肝细胞中极低密度脂蛋白的组装。

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5mg

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货号: ajce54700
CAS: 623-58-5
别名: 乙酰乙酸钠
分子式: C4H5NaO3
分子量: 124.07
纯度: >98%
溶解度: Water: 50 mg/mL (403.00 mM)
储存: Store at -20°C,unstable in solution, ready to use.
库存: 现货

Background

Acetoacetic acid sodium salt is a metabolite of non-esterified fatty acids, involved in the development of human diabetes. Acetoacetic acid sodium salt induces oxidative stress to inhibit the assembly of very low density lipoprotein in bovine hepatocytes[1].

Acetoacetic acid sodium salt induces oxidative stress to inhibit the assembly of very low density lipoprotein in bovine hepatocytes[1].Acetoacetic acid (0.6, 2.4, 4.8 mM) increases malondialdehyde (MDA) content in high-dose group (GH) group, decreases mRNA expression of Mn SOD, Cu/Zn SOD, and glutathione peroxidase (GSH-Px) in all groups, lowers catalase (CAT) mRNA expression in medial-dose group (GM), and GH groups. In addition, Acetoacetic acid down-regulates the mRNA expression of apolipoprotein B100 (ApoB100), apolipoprotein E (ApoE), and low density lipoprotein receptor (LDLR). Thus, VLDL assembly is decreased andtriglyceride (TG) accumulation is increased in these bovine hepatocytes[1].

参考文献:
[1]. Shi X, et al. Acetoacetic acid induces oxidative stress to inhibit the assembly of very low density lipoprotein in bovine hepatocytes. J Dairy Res. 2016 Nov;83(4):442-446.