Argatroban monohydrate

A thrombin inhibitor

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库存: 现货

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促销价

数量
10mg

￥700.00

560.00

- +
50mg

￥2112.00

1690.00

- +
100mg

￥3162.00

2530.00

- +
200mg

￥0.00

0.00

- +
500mg

￥0.00

0.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajce55010
CAS: 141396-28-3
别名: 阿加曲班一水合物; MD-805 monohydrate; MCI-9038 monohydrate; Argipidine monohydrate
分子式: C23H38N6O6S
分子量: 526.65
纯度: >98%
溶解度: DMSO: ≥ 100 mg/mL (189.88 mM); Water: < 0.1 mg/mL (insoluble)
储存: 4°C, protect from light
库存: 现货

Background

Argatroban is a reversible inhibitor of thrombin (IC₅₀s = 0.01 and 0.09 ?M for the free and clot-bound forms, respectively).¹ It is selective for thrombin over factor Xa, trypsin, plasmin, and tissue plasminogen activator (K_is = 0.0045, 53, 0.19, 25.7, and 87.7 ?M, respectively). It inhibits thrombin-induced platelet aggregation in washed isolated guinea pig platelets with an IC₅₀ value of 0.077 ?M.² Argatroban (3.2 mg/kg, s.c.) decreases thrombus formation in a guinea pig model of iron chloride-induced arterial thrombosis. Formulations containing argatroban have been used in the prevention or treatment of thrombosis in patients with heparin-induced thrombocytopenia.

1.Park, H.D., Lee, S.H., Kim, T.H., et al.Antithrombotic effects of LB30870, a potent, orally active, selective and direct thrombin inhibitor, and pharmacokinetics of its prodrugBioorg. Med. Chem. Lett.23(17)4779-4784(2013) 2.Kato, Y., Kita, Y., Hirasawa-Taniyama, Y., et al.Inhibition of arterial thrombosis by a protease-activated receptor 1 antagonist, FR171113, in the guinea pigEur. J. Pharmacol.473(2-3)163-169(2003)