Bioymifi

A DR5 agonist

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
5mg

￥775.00

620.00

- +
10mg

￥1300.00

1040.00

- +
25mg

￥2937.00

2350.00

- +
50mg

￥5175.00

4140.00

- +
100mg

￥9287.00

7430.00

- +
200mg

￥0.00

0.00

- +
500mg

￥0.00

0.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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Background

Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TNF-related apoptosis-inducing ligand (TRAIL or Apo2L), a member of this family, activates apoptosis in a variety of tumor cell lines by signaling through the death receptors, DR4 and DR5. Bioymifi directly activates DR5 (K_d = 1.2 ?M; IC₅₀ = 2 ?M), inducing DR5 clustering, which leads to the initiation of FADD/caspase-8-dependent apoptosis in various cancer cells.¹

1.Wang, G., Wang, X., Yu, H., et al.Small-molecule activation of the TRAIL receptor DR5 in human cancer cellsNat. Chem. Biol.984-90(2012)