Camelliaside A

A flavonoid with radical scavenging and enzyme inhibitory activities

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Background

Camelliaside A is a flavonoid that has been found in C. sinensis and has radical scavenging and enzyme inhibitory activities.^1,2,3,4 It scavenges superoxide radicals in a cell-free assay (IC₅₀ = 137.44 ?M).¹ Camelliaside A (1 ?M) inhibits recombinant human monoamine oxidase B (MAO-B) in a cell-free assay.⁴ It also inhibits 5-lipoxygenase (5-LO) in RBL-1 rat basophilic leukemia cells (IC₅₀ = 390 ?M).³

1.Kang, B., Chang, H., Na, Y.J., et al.Extract of enzyme-hydrolyzed green tea seed as potent melanin synthesis inhibitorBull. Korean Chem. Soc.34(7)2199-2202(2013) 2.Park, J.S., Rho, H.S., Kim, D.H., et al.Enzymatic preparation of kaempferol from green tea seed and its antioxidant activityJ. Agric. Food Chem.54(8)2951-2956(2006) 3.Sekine, T., Arai, Y., Ikegami, F., et al.Isolation of camelliaside C from "tea seed cake" and inhibitory effects of its derivatives on arachidonate 5-lipoxygenaseChem. Pharm. Bull. (Tokyo)41(6)1185-1187(1993) 4.Shkondrov, A., Krasteva, I., Bucar, F., et al.A new tetracyclic saponin from Astragalus glycyphyllos L. and its neuroprotective and hMAO-B inhibiting activityNat. Prod. Res.34(4)511-517(2020)