Cephalotaxlen

An alkaloid with anticancer and antiviral activities

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
5mg

￥550.00

440.00

- +
10mg

￥800.00

640.00

- +
50mg

￥2487.00

1990.00

- +
100mg

￥4150.00

3320.00

- +
200mg

￥0.00

0.00

- +
500mg

￥0.00

0.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajce55548
CAS: 24316-19-6
别名: 三尖杉碱; (-)-Cephalotaxine; ZINC19795976
分子式: C18H21NO4
分子量: 315.36
纯度: >98%
溶解度: DMSO: ≥ 100 mg/mL (317.10 mM)
储存: Store at -20°C
库存: 现货

Background

Cephalotaxine is an alkaloid that has been found in Cephalotaxus and has anticancer and antiviral activities.^1,2,3 It is cytotoxic to HL-60, NB4, MOLT-4, K562, Jurkat, and Raji cells (IC₅₀s = 4.91, 16.88, 7.09, 22.59, 5.54, and 18.08 ?M, respectively).¹ Cephalotaxine (5-20 ?M) induces mitochondrial apoptosis, as well as impairs lysosomal acidification and autophagic flux in HL-60 cells. It reduces infectivity and hepatitis B virus (HBV) surface antigen (HBsAg) secretion in HBV-infected HepG2 2.2.15 cells when used at concentrations ranging from 10 to 100 ?M.² Cephalotaxine (20, 40, and 80 ?M) also reduces viral infectivity in Zika virus-infected Vero cells.³

1.Liu, T., Guo, Q., Zheng, S., et al.Cephalotaxine inhibits the survival of Leukemia cells by activating mitochondrial apoptosis pathway and inhibiting autophagy flowMolecules26(10)2996(2021) 2.Romero, M.R., Serrano, M.A., Efferth, T., et al.Effect of cantharidin, cephalotaxine and homoharringtonine on "in vitro" models of hepatitis B virus (HBV) and bovine viral diarrhoea virus (BVDV) replicationPlanta Med.73(6)552-558(2007) 3.Lai, Z.-Z., Ho, Y.-J., and Lu, J.-W.Cephalotaxine inhibits Zika infection by impeding viral replication and stabilityBiochem. Biophys. Res. Commun.22(4)1052-1058(2020)