DL-Homocystine

An oxidized dimeric form of homocysteine

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货号: ajce55996
CAS: 870-93-9
别名: DL-高胱氨酸
分子式: C8H16N2O4S2
分子量: 268.35
纯度: >98%
溶解度: Water: 10 mg/mL (37.26 mM; ultrasonic and adjust pH to 11 with NaOH); DMSO: < 1 mg/mL (insoluble or slightly soluble); Water: < 0.1 mg/mL (insoluble)
储存: Store at -20°C
库存: 现货

Background

DL-Homocystine is an oxidized dimeric form of homocysteine . It inhibits CDNB-induced L-cystine transport into isolated human erythrocytes by 75% when used at a concentration of 2.5 mM.¹ DL-Homocystine increases the number of circulating endothelial cells and permeability of the pulmonary microcirculation and decreases the number of circulating platelets, as well as activates venostatic thrombosis induced by bowel loop ligation in a rat model of homocystinemia, an inborn error of metabolism characterized by a deficiency in cystathionine β-synthase (CBS) that is associated with thrombosis and atherosclerosis.²

1.Ohtsuka, Y., Kondo, T., and Kawakami, Y.Oxidative stresses induced the cystine transport activity in human erythrocytesBiochem. Biophys. Res. Commun.155(1)160-166(1988) 2.Hladovec, J.Experimental homocystinemia, endothelial lesions and thrombosisBlood Vessels16(4)202-205(1979)