Lomitapide mesylate

An MTTP inhibitor

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
10mg

￥1262.00

1010.00

- +
50mg

￥2962.00

2370.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajce57198
CAS: 202914-84-9
别名: 甲磺酸洛美他派; AEGR-733 mesylate; BMS-201038 mesylate
分子式: C40H41F6N3O5S
分子量: 789.83
纯度: >98%
溶解度: DMSO : ≥ 100 mg/mL (144.15 mM)
储存: Store at -20°C
库存: 现货

Background

Lomitapide is an inhibitor of microsomal triglyceride transfer protein (MTTP; IC₅₀ = 0.5 nM in a triglyceride transfer assay).¹ It inhibits apolipoprotein B (ApoB) secretion in HepG2 cells (EC₅₀ = 0.8 nM). Lomitapide inhibits triglyceride secretion in fasted rats (ED₅₀ = 0.19 mg/kg, p.o.) and reduces total plasma cholesterol levels in hamsters (ED₅₀ = 2.4 mg/kg). It also decreases plasma cholesterol and triglyceride levels in the Watanabe-heritable hyperlipidemic (WHHL) rabbit model of homozygous familial hypercholesterolemia when administered at a dose of 10 mg/kg. Formulations containing lomitapide have been used as an adjunct to a low-fat diet and other lipid-lowering treatments in the treatment of homozygous familial hypercholesterolemia.

1.Wetterau, J.R., Gregg, R.E., Harrity, T.W., et al.An MTP inhibitor that normalizes atherogenic lipoprotein levels in WHHL rabbitsScience282(5389)751-754(1998)