Loxoprofen

An NSAID and a prodrug form of loxoprofen-SRS

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10mg

￥425.00

340.00

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50mg

￥600.00

480.00

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100mg

￥837.00

670.00

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200mg

￥1025.00

820.00

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500mg

￥0.00

0.00

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1g

￥0.00

0.00

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Background

Loxoprofen is a non-steroidal anti-inflammatory drug (NSAID) and prodrug form of loxoprofen-SRS.¹ It inhibits COX-1 and COX-2 in isolated human whole blood (IC₅₀s = 6.5 and 13.5 ?M, respectively). Loxoprofen reduces acetic acid-induced writhing in mice and carrageenan-induced paw edema and LPS-induced fever in rats (ED₃₀s = 20.1, 0.7, and 2.79 mg/kg, respectively).² Formulations containing loxoprofen have been used in the treatment of pain associated with osteoarthritis, myalgia, and post-traumatic swelling.

1.Riendeau, D., Salem, M., Styhler, A., et al.Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2Bioorg. Med. Chem. Lett.14(5)1201-1203(2004) 2.Futaki, N., Yoshikawa, K., Hamasaka, Y., et al.NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesionsGen. Pharmacol.24105-110(1993)