An NSAID and a prodrug form of loxoprofen-SRS
Loxoprofen is a non-steroidal anti-inflammatory drug (NSAID) and prodrug form of loxoprofen-SRS.1 It inhibits COX-1 and COX-2 in isolated human whole blood (IC50s = 6.5 and 13.5 ?M, respectively). Loxoprofen reduces acetic acid-induced writhing in mice and carrageenan-induced paw edema and LPS-induced fever in rats (ED30s = 20.1, 0.7, and 2.79 mg/kg, respectively).2 Formulations containing loxoprofen have been used in the treatment of pain associated with osteoarthritis, myalgia, and post-traumatic swelling.
1.Riendeau, D., Salem, M., Styhler, A., et al.Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2Bioorg. Med. Chem. Lett.14(5)1201-1203(2004) 2.Futaki, N., Yoshikawa, K., Hamasaka, Y., et al.NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesionsGen. Pharmacol.24105-110(1993)
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