Porcine dynorphin A(1-13)

Porcine dynorphin A (1-13) 是一个有效的内源性阿片受体 (κ opioid receptor) 激动剂，在生理浓度下它有镇痛作用。

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1mg

￥762.00

610.00

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5mg

￥1625.00

1300.00

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25mg

￥5287.00

4230.00

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50mg

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100mg

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货号: ajce58136
CAS: 72957-38-1
别名: 强啡肽A(1-13),Dynorphin A Porcine Fragment 1-13
分子式: C75H126N24O15
分子量: 1603.96
纯度: >98%
溶解度: Water: ≥ 60 mg/mL (37.41 mM)
储存: Store at -20°C
库存: 现货

Background

Porcine dynorphin A (1-13) is a potent, endogenous κ opioid receptor agonist and is antinociceptive at physiological concentrations.

Dynorphin A (1-13) exposure (33 μM) causes a significant loss in neuronal viability at 4 h with a visible destruction in neuronal morphology seen at 16 h. Exposure to dynorphin A (1-13) causes acute increases in [Ca2+]i in individual neurons similar to increases seen with acute NMDA treatment. Continuous exposure to dynorphin A (1-13) (100 μM) causes a significant loss of neurons over time[1].

参考文献:
[1]. Hauser KF, et al. Dynorphin A (1-13) neurotoxicity in vitro: opioid and non-opioid mechanisms in mouse spinal cord neurons. Exp Neurol. 1999 Dec;160(2):361-75.