Racanisodamine

A natural α1-adrenoceptor antagonist

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库存: 现货

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100mg

￥700.00

560.00

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500mg

￥1525.00

1220.00

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1g

￥0.00

0.00

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5g

￥0.00

0.00

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货号: ajce58370
CAS: 17659-49-3
别名: 消旋山莨菪碱
分子式: C17H23NO4
分子量: 305.37
纯度: >98%
溶解度: 25mg in ethanol or DMF, 20mg/mL in DMSO
储存: Store at -20°C
库存: 现货

Background

Racanisodamine is a natural tropane alkaloid shown to be a weak antagonist of α₁-adrenoceptors, blocking WB-4101 and clonidine binding in brain membrane preparations with pK_i values of 2.63 and 1.61, respectively.¹ Racanisodamine also has antioxidant effects that may protect against free radical-induced cellular damage.² Racanisodamine is predominantly found in the roots of A. tanguticus, which is used in traditional Chinese medicine for topical applications.³

1.Varma, D.R., and Yue, T.L.Adrenoceptor blocking properties of atropine-like agents anisodamine and anisodine on brain and cardiovascular tissues of ratsBr. J. Pharmacol.87(3)587-594(1986) 2.Poupko, J.M., Baskin, S.I., and Moore, E.The pharmacological properties of anisodamineJ. Appl. Toxicol.27(2)116-121(2007) 3.Ma, L., Gu, R., Tang, L., et al.Important poisonous plants in Tibetan ethnomedicineToxins (Basel)7(1)138-155(2015)