TBPB

An allosteric agonist of M1 receptors

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库存: 现货

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数量
10mg

￥675.00

540.00

- +
50mg

￥2112.00

1690.00

- +
100mg

￥3775.00

3020.00

- +
200mg

￥7137.00

5710.00

- +

已选 0 种 0 瓶

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货号: ajce59740
CAS: 634616-95-8
别名:
分子式: C25H32N4O
分子量: 404.55
纯度: >98%
溶解度: DMSO: 22.5 mg/mL (55.62 mM and warming)
储存: Store at -20°C
库存: 现货

Background

TBPB is an allosteric agonist of M₁ muscarinic acetylcholine receptors (mAChRs; EC₅₀ = 158 nM in CHO-K1 cells expressing rat recombinant receptors).¹ It is selective for M₁ over M_2-5 receptors at concentrations up to 10 μM. TBPB (3 μM) potentiates NMDA-evoked currents in CA1 pyramidal cells. It increases production of the non-amyloidogenic amyloid precursor protein (APP) cleavage products APP_sα and CTFα in PC12 cells overexpressing the human M₁ receptor and APP when used at a concentration of 1 μM. TBPB decreases amphetamine-induced hyperlocomotion in a rat model that is predictive of antipsychotic-like activity.

1.Jones, C.K., Brady, A.E., Davis, A.A., et al.Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in ratsJ. Neurosci.28(41)10422-10433(2008)